BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Alexander James Dallas' An Exposition of the Causes and Character of the War was written as part of an effort by the then US government to explain and justify its declaration of war in 1812. However publication coincided with the ratification of the Treaty of Ghent, which ended the War. The Exposition is especially interesting for the insight it provides into the self-constraint of American foreign policy and of the conduct of a war. The focus is on the foreign policy (...) of the early republic and the related philosophy of law and war. A central idea is that international law should chiefly benefit those remaining at peace. -/- Dallas was a Philadelphian who settled there in 1783, the year of the Peace of Paris which ended the War of Independence, arriving from Jamaica after a British education. He wrote much on law, becoming the first recorder of cases before the U.S. Supreme Court. He later served as Secretary of the Commonwealth of Pennsylvania, and federal district attorney for Eastern Pennsylvania, appointed by President Jefferson. He was appointed Secretary of Treasury by President Madison. -/- In this edition the original text is presented with annotations to help identify persons and events of interest. The editor has also added an Introduction, a Bibliography, a short Chronology of Dallas' life and the events of the War, and an analytical Index. As such this annotated edition presents a key primary source in a manner helpful to research for students of the early Republic. (shrink)

Mimesis can refer to imitation, emulation, representation, or reenactment - and it is a concept that links together many aspects of ancient Greek Culture. The Western Greek bell-krater on the cover, for example, is painted with a scene from a phlyax play with performers imitating mythical characters drawn from poetry, which also represent collective cultural beliefs and practices. One figure is shown playing a flute, the music from which might imitate nature, or represent deeper truths of the cosmos based upon (...) Pythagorean views (which were widespread in Western Greece at the time). The idea that mimesis should be restricted to ideals was made famous by Plato (whose connections to Pythagoreanism and Siracusa are well-known), and famously challenged by his student Aristotle (not to mention by the mimetic character of Plato’s own poetry). This volume gathers essays not only on the philosophical debate about mimesis, but also on its use in architecture, drama, poetry, history, music, ritual, and visual art. The emphasis is on examples from Hellenic cities in Southern Italy and Sicily, but the insights apply far beyond – even to modern times. Contributors include: Thomas Noble Howe, Francisco J. Gonzalez, Gene Fendt, Guilherme Domingues da Motta, Jeremy DeLong, Carolina Araújo, Marie-Élise Zovko, Lidia Palumbo, Sean Driscoll, Konstantinos Gkaleas, Anna Motta, Jure Zovko, Alexander H. Zistakis, Christos C. Evangeliou, Dorota Tymura, Iris Sulimani, Elliott Domagola, Jonah Radding, Giulia Corrente, Laura Tisi, Ewa Osek, Argyri G. Karanasiou, Rocío Manuela Cuadra Rubio, Jorge Tomás García, Aura Piccioni, and José Miguel Puebla Morón. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & The Environment 25th Anniversary Issue:Introduction from the EditorPiers H.G. StephensAt the time that Vicky Davion conceived of and launched Ethics and the Environment twenty-five years ago, environmental philosophy was still struggling for acceptance and respectability as a philosophical subdiscipline. For most of the period since 1979 just one journal, Environmental Ethics, had been the primary beacon of the field, and a second, the United Kingdom-based Environmental Values, (...) had only started up in 1992. Much of the surrounding professional atmosphere at the time was less than congenial, especially in relation to any attempt to engage in philosophical radicalism via environmental thought, with much institutional pressure pushing towards seeing all the concerns of our nascent field as questions to be shuffled off into a subsection of applied ethics. As someone who was beginning my doctoral studies in Britain around that time, I well recall the pressures and the struggle for respectability that was involved, and such conditions made the bar for success in launching a new journal that much higher. Vicky's actions in beginning the journal thus required not only imagination and creativity, but a significant amount of intellectual courage.This courage manifested itself most obviously in the new ground that Ethics and the Environment set out to break. Environmental Ethics had tended to take much of its inspiration from the American conservation and preservation movements as well as debates over intrinsic value, while Environmental Values took a perspective that bridged these concerns to predominantly British political and economic theory, Ethics and the Environment responded to the institutional challenges facing the new field by broadening the range of voices and critique that environmental [End Page 1] philosophy articulated. From the earliest stages, radical perspectives that were unrepresented or underrepresented in the other journals—especially ecofeminism, deep ecology, indigenous and non-Western thought—were central to the identity and mission of Ethics and the Environment, and gave it a distinctive place and appeal. It was a risky strategy to take in the mid 1990s, yet it proved to be not only the right thing to do, broadening the debate and adding new protagonists, but also a path to produce a highly successful journal over time.Ethics and the Environment is today one of the top journals in environmental philosophy, still growing in its subscriptions and influence, and a living tribute to the quality of Vicky Davion's vision. As editor, I am often astounded at the range, diversity, and quality of the manuscript submissions we receive from a global audience, and though I remain saddened at the circumstances under which I took over the editorship, I am proud and grateful to be in charge of such a publication, and holding fast as best I can to its founding vision as the journal nears its 25th anniversary. Within the field of environmental philosophy Ethics and the Environment is deeply associated with our department and with the University of Georgia, and I hope that it may continue to be so for many a long year yet. [End Page 2]Copyright © 2020 The Trustees of Indiana University... (shrink)

Traditionally, empathy is conceived of as a cognitive function that governs how people think during social interactions, and is considered as largely impervious to change. However, developments in psychology and neuroscience show that empathy is grounded in neural substrates of emotionally communicative behaviour and so is learned through imitation and other forms of cultural learning. This also means that abnormal patterns of empathic function can develop through adverse life experiences, or that empathy may fail to develop in young people with (...) neurodevelopmental disorders. Nevertheless, by focussing on empathy as a quality of social interaction and affective expression in the here and now, and by appreciating that it is as a special form of sensorimotor skill, pathways to training and fostering better development of empathy can be identified. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Message from the EditorPiers H.G. Stephens, EditorIt is now six years since this journal’s founding editor Victoria Davion sadly succumbed to premature fatal illness and I took over her editorial duties under the most unfortunate of circumstances. I stated publicly then that Vicky’s vision for the character and purpose of the journal would remain unchanged under my watch, and in keeping with that pledge, I am now pleased (...) to announce a major expansion of our editorial board to further promote that vision.Over the past two decades, the size of our board had declined significantly as a result of retirements and mortality, and so a restoration of the previous scale of editorial support was significantly overdue. In doing this, I have sought to protect and expand our international and interdisciplinary coverage in a way that honors the focus that Vicky gave the journal from the beginning, giving space to voices from the wider communities of concern impacted by ecological destruction and incorporating a broad and inclusive but critically engaged approach to the philosophical issues involved. Our new board includes members from a wider range of nations and disciplines, which should help us expand the journal’s reach while both manifesting and remaining faithful to the original mission that our founding editor set for it. In the process, we are welcoming a combination of new rising stars and well-established respected figures in environmental thought, and aiming to expand our sphere of influence well beyond our main subscriber base in North America. Our hope is that our new scholarly supporters will enable the journal to grow in tackling the newer and ever more complex issues and problems raised by climate change, biodiversity loss, and other ongoing ecological crises, while at the same time still remaining true to the spirit with which Vicky founded it.Readers, please join me in welcoming our new board members, who are listed in the front matter of this issue. We thank them immensely for their service and hope that their efforts will enable and support increased success for Ethics and the Environment. [End Page 1]Copyright © 2023 The Trustees of Indiana University... (shrink)